2014 FEI Image Contest Monthly Winners

2014 FEI Image Contest Monthly Winners

Dendritic Cell

Courtesy of Prof. David Pérez-Morga

False-colored SEM image of a migrating mouse dendritic cell (5.2 µm), showing membrane projections known as lamellipodia (green). Dendritic cells are sentinels of the immune system that are posted in peripheral tissues, ingest intruders and then migrate to the lymphoid organs. There, they expose some of their digested protein fragments (antigens) using their cell membrane as a showcase, report on the intruder and interact with- and instruct effector immune cells known as T-lymphocytes. Sophie Uzureau, Daniel Monteyne, Etienne pays and David Pérez-Morga, Université libre de Bruxelles.

Image Details
Instrument used: Quanta SEM
Magnification: 19588.2x
Horizontal Field Width: 3.584 µm
Voltage: 20 kV
Spot: 3.0
Detector: ETD SE

Nikon Small World 2013 Photomicrography Competition

Une photographie prise au CMMI reçoit une honorable mention au “Nikon Small World 2013 Photomicrography Competition”. La photographie représente une valvule entérique de termite, observée au microscope confocal à balayage laser grâce à son autofluorescence naturelle. Le spécimen provient du laboratoire d’Evolution Biologique et Ecologie de l’ULB avec qui le CMMI entretient une collaboration.Une photographie prise au CMMI reçoit une honorable mention au “Nikon Small World 2013 Photomicrography Competition”. La photographie représente une valvule entérique de termite, observée au microscope confocal à balayage laser grâce à son autofluorescence naturelle. Le spécimen provient du laboratoire d’Evolution Biologique et Ecologie de l’ULB avec qui le CMMI entretient une collaboration.

Trypanosoma : Discovery About the mecanism allowing some parasites to infect humans

Sleeping sickness is caused by a parasite: trypanosoma. In a new research published in Nature, the Molecular Parasitology lab (IBMM) publish a breakthrough discovery about the mecanism allowing some parasites to infect humans.
In 2003, En 2003, Pr Etienne Pays’ team already discovered that humans are naturally protected againts this type of pathogens owing to a serum protein called apolipoprotein L1 (apoL1), which efficiently kills the parasite by generating ionic pores in membranes of its digestive system. Through evolution, two variant trypanosomes acquired the ability to resist apoL1. These variant trypanosomes, named Trypanosoma rhodesiense and Trypanosoma gambiense, can therefore grow in human blood. It’s the mecanism which allows those parasite to resist to apoL-1 and infect humans that the researchers demonstrate today.

See:
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12516.html?WT.ec_id=NATURE-20130822
http://www.bbc.co.uk/news/health-23755038
http://www.lesoir.be/303294/article/actualite/sciences-et-sante/2013-08-22/mystere-maladie-du-so

SCIENCE COVER

False-colored scanning electron microscopy image of innate immune cells and the parasite Trypanosoma brucei (purple; length: 15 micrometers) in an infected mouse liver. The parasite is transmitted between mammalian hosts, including humans, by the bite of infected tsetse flies and is responsible for human sleeping sickness, a lethal disease that is a serious problem in Africa. See page 463. Image: Gilles Vanwalleghem, Daniel Monteyne, Etienne Pays, and David Pérez-Morga, Laboratory of Molecular Parasitology and Center for Microscopy and Molecular Imaging, Université libre de Bruxelles, Gosselies, Belgium
See the website:

http://www.sciencemag.org/content/337/6093.cover-expansion