The CMMI will give a seminar to present its activities at the IRIBHM on April 12, at 13:00. You are working on the Erasme campus? Come and meet us !

The CMMI is happy to announce the publication of a study led by our colleagues of the Molecular Physiology of the Cell lab of the ULB.
Congratulations to Céline Barthelemy, Abdoulaye Oury BARRY and Bruno André as well as to our deputy director Laure Twyffels who contributed to the confocal fluorescence microscopy part.

The study explores the effect of the anticancer agent FTY720 on yeast and human cells. FTY720 was already known to “starve cancer cells to death” (10.1002/1873-3468.12121).  The present study better explains how: it shows that FTY720 reduces the activity of several plasma membrane amino acids permeases. This decreases the ability of cells to import amino acids, which, in turn, triggers a positive feed-back mechanism that leads to the endocytosis of these permeases via the inhibition of TORC1, and a further decrease in amino acid import capability.


11A picture acquired at the CMMI is featured as the cover of Nature Microbiology this week. Congratulations to our electron microscopy team !

NobelPrizesThanks to the continued support of the Walloon Region and the ERDF, the CMMI will soon propose cryo-TEM services to its academic and industrial partners.

We are therefore very happy to share that the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution”. We too find that it is a “super cool” technology (☺!)

Humans are protected against African trypanosomes by the serum protein APOL1; however, Trypanosoma rhodesiense and Trypanosoma gambiense neutralize this defense and cause sleeping sickness. Fontaine et al. found that APOL3 is also able to kill both species and consequently engineered a therapeutic version of APOL1 that eradicates infection by T. gambiense in mice.

APOLs with low pH dependence can kill all African trypanosomes

TEM imaging of T.b. brucei during lysis

Frédéric Fontaine, Laurence Lecordier, Gilles Vanwalleghem, Pierrick Uzureau, Nick Van Reet, Martina Fontaine, Patricia Tebabi, Benoit Vanhollebeke, Philippe Büscher, David Pérez-Morga and Etienne Pays

Summer publications of the CMMI… Congratulations to our collaborators !

Summer publications of the CMMI… Congratulations to our collaborators !

Nanofitin as a new molecular imaging agent for diagnosis of EGFR overexpressing tumors.
Goux M, Becker G, Gorré H, Dammicco S, Desselle A, Egrise D, Leroi N, Lallemand F, Bahri MA, Doumont G, Plenevaux A, Cinier M, Luxen A.
Bioconjug Chem. 2017 Aug 21. doi: 10.1021/acs.bioconjchem.7b00374.

Synthesis and characterization of monophosphinic acid DOTA derivative: A smart tool with functionalities for multimodal imaging.
Chilla SNM1, Zemek O2, Kotek J3, Boutry S4, Larbanoix L4, Sclavons C4, Elst LV4, Lukes I3, Muller RN4, Laurent S5.
Bioorg Med Chem. 2017 Aug 15;25(16):4297-4303. doi: 10.1016/j.bmc.2017.06.008. Epub 2017 Jun 15.

Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes.gr4Vindry C1, Marnef A2, Broomhead H1, Twyffels L3, Ozgur S4, Stoecklin G5, Llorian M1, Smith CW1, Mata J1, Weil D6, Standart N7.
Cell Rep. 2017 Aug 1;20(5):1187-1200. doi: 10.1016/j.celrep.2017.06.091.

Long-Term In Vivo Monitoring of Adult-Derived Human Liver Stem/Progenitor Cells by Bioluminescence Imaging, Positron Emission Tomography, and Contrast-Enhanced Computed Tomography.Longitudinal tracking of ADHLSCs by BLIHsu MJ1, Prigent J1, Dollet PE1, Ravau J1, Larbanoix L2,3, Van Simaeys G2,4, Bol A5, Grégoire V5, Goldman S2,4, Deblandre G1, Najimi M1, Sokal EM1,6, Lombard CA1.
Stem Cells Dev. 2017 Jul 1;26(13):986-1002. doi: 10.1089/scd.2016.0338. Epub 2017 Jun 5.