The CMMI is happy to announce the publication of a study led by our colleagues of the Molecular Physiology of the Cell lab of the ULB.
Congratulations to Céline Barthelemy, Abdoulaye Oury BARRY and Bruno André as well as to our deputy director Laure Twyffels who contributed to the confocal fluorescence microscopy part.
The study explores the effect of the anticancer agent FTY720 on yeast and human cells. FTY720 was already known to “starve cancer cells to death” (10.1002/1873-3468.12121). The present study better explains how: it shows that FTY720 reduces the activity of several plasma membrane amino acids permeases. This decreases the ability of cells to import amino acids, which, in turn, triggers a positive feed-back mechanism that leads to the endocytosis of these permeases via the inhibition of TORC1, and a further decrease in amino acid import capability.