All posts by Cedric Verbelen

From temperature imaging to brain development, including one of our most recurrent topics: cancer. Latest publications of the CMMI.

Photoacoustic temperature imaging based on multi-wavelength excitation.
Meng L, Deschaume O, Larbanoix L, Fron E, Bartic C, Laurent S, Van der Auweraer M, Glorieux C
Photoacoustics 2019 Mar; 13: 33-45

DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors.
Desmaris E, Keruzore M, Saulnier A, Ratié L, Assimacopoulos S, De Clercq S, Nan X, Roychoudhury K, Qin S, Kricha S, Chevalier C, Lingner T, Henningfeld KA, Zarkower D, Mallamaci A, Theil T, Campbell K, Pieler T, Li M, Grove EA, Bellefroid EJ.
J Neurosci. 2018 Oct 17;38(42):9105-9121. doi: 10.1523/JNEUROSCI.0375-18.2018. Epub 2018 Aug 24.

Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells.
Ghosh S, Scozzaro S, Ramos AR, Delcambre S, Chevalier C, Krejci P, Erneux C.
J Cell Sci. 2018 Aug 16;131(16). pii: jcs216408. doi: 10.1242/jcs.216408.

YAP and TAZ are essential for basal and squamous cell carcinoma initiation.
Debaugnies M, Sánchez-Danés A, Rorive S, Raphaël M, Liagre M, Parent MA, Brisebarre A, Salmon I, Blanpain C.
EMBO Rep. 2018 Jul;19(7). pii: e45809. doi: 10.15252/embr.201845809. Epub 2018 Jun 6.

Summer publications of the CMMI/Special focus: how do cells decode the various Wnt signaling pathways

Wnt signaling is key to several important processes, both in health and disease. The genes encoding the Wnt ligand and its receptor Frizzled have undergone extensive duplications during evolution, but how vertebrate cells are able to “decode” their 19 Wnt ligands and therefore make a variety of functions emerge from this genetic diversity was still largely unknown.

In “A molecular mechanism for Wnt ligand-specific signaling”, published this summer in Science, our colleague Benoit Vanhollebeke, his team and collaborators from the UCL NanoBiophysics Lab and Max Planck Institute for lung and heart research found some important pieces of the puzzle of Wnt signaling diversity. They dissect the molecular mechanism for Wnt7-specific signaling and unravel the central role played by Reck, GPR124 and Dishevelled the process. It can be hypothesized that other Wnt or Frizzled family members are decoded in a similar manner through other accessory proteins.


A molecular mechanism for Wnt ligand-specific signaling.
Eubelen M, Bostaille N, Cabochette P, Gauquier A, Tebabi P, Dumitru AC, Koehler M, Gut P, Alsteens D, Stainier DYR, Garcia-Pino A, Vanhollebeke B.
Science. 2018 Aug 17;361(6403). pii: eaat1178. Epub 2018 Jul 19.

Summer publications of the CMMI/Special focus: research in image analysis conducted by the DIAPath team of the CMMI

Image analysis is one of the strong points of our digital pathology team DIAPath. In a recent article, our colleagues at DIAPath explain how they used deep learning and data augmentation techniques to automate annotation of histological slide images from colorectal tissue. Their method segments glandular epithelium in images from tissue slides stained with hemaetoxylin & eosin or by immunohistochemistry (IHC). It is robust, outperforms pre-existing methods and concurs highly with manual annotations, thereby enabling the compatimentalization of IHC quantification.

Segmentation of glandular epithelium in colorectal tumours to automatically compartmentalise IHC biomarker quantification: A deep learning approach.
Van Eycke YR, Balsat C, Verset L, Debeir O, Salmon I, Decaestecker C.
Med Image Anal. 2018 Jul 12;49:35-45.

Summer publications of the CMMI

What an exciting year! Many articles that benefited from the team and/or infrastructure of the CMMI were published in the last months. Some of them are below. A special focus on two additional CMMI articles will follow in the coming days. Congratulations to our collaborators for the good work!

Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells.
Bar I, Merhi A, Larbanoix L, Constant M, Haussy S, Laurent S, Canon JL, Delrée P.
Oncotarget. 2018 Jul 20;9(56):30821-30836. eCollection 2018 Jul 20

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties.
Givord C, Welsby I, Detienne S, Thomas S, Assabban A, Lima Silva V, Molle C, Gineste R, Vermeersch M, Perez-Morga D, Leo O, Collignon C, Didierlaurent AM, Goriely S.
NPJ Vaccines. 2018 Jun 28; 3:20. eCollection 2018.

Chitosan-coated liposome dry-powder formulations loaded with ghrelin for nose-to-brain delivery.
Salade L, Wauthoz N, Vermeersch M, Amighi K, Goole J.
Eur J Pharm Biopharm. 2018 Aug; 129:257-266. Epub 2018 Jun 15.

Effects of press-fit biphasic (collagen and HA/βTCP) scaffold with cell-based therapy on cartilage and subchondral bone repair knee defect in rabbits.
Hernigou J, Vertongen P, Chahidi E, Kyriakidis T, Dehoux JP, Crutzen M, Boutry S, Larbanoix L, Houben S, Gaspard N, Koulalis D, Rasschaert
J. Int Orthop. 2018 Jun 7.

New cryo-TEM Talos F200C

Summer began with a special delivery at the CMMI : our new cryo-TEM, a Talos F200C, arrived last Friday under a bright sun.

This exceptional microscope and its accessories were arranged in 15 boxes, the heaviest of which weighted no less than 1740 kg.

Bringing everything to the premises of the CMMI was not a trivial operation, but everything ended well and the microscope is now at its final position.

Minor works will be performed during the summer so as to complete the installation by September.

This will be the end of a long process… and the beginning of exciting scientific adventures!

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The CMMI selected as finalist for the RegioStars 2018

Great news! We’ve been selected as finalist in the “Supporting smart industrial transition” category for the RegioStars 2018.
RegioStars are European awards that identify good practices in regional development and highlight original and innovative projects that are attractive and inspiring to other regions.

We are very proud to have been selected, and thankful to all our partners, especially to the Biopark and to the Walloon Region!

Facebook_RegioStarsFinalist 2018