Applications and description
The nuMIx lab is specialized in preclinical nuclear imaging in vivo and ex vivo. nuMix is proposing services in quantitative digital autoradiography using a last generation MicroImager detector (Biospace Lab, France).
Autoradiography is a high-resolution (μm range) and high-sensitivity 2D molecular imaging technique depicting radiation distribution in histological (ex vivo) slices. In Autoradiography particles originating from the radiotracer incorporated in the slices are routinely recorded on a radiosensitive film or emulsion placed in direct contact with the specimen.
A new generation system, the MicroImager™ acquired by the CMMI delivers autoradiography data in a digital form due to the scintillating emulsion being coupled to a cooled and intensifing CCD camera. The MicroImager™ allows real-time image formation and quantitation without under- or overexposure, with an outstanding sensitivity by many orders of magnitude better than standard techniques. Additionally, the MicroImager™ enables direct quantitation of patterns of radiotracer distribution (real counting of detected particles from slices), as well as simultaneous imaging and discrimination of different radionuclides in specimens with multiple radiolabelling.
- Micro-Imager (Biospace Lab, France)
|Facility manager||Academic supervisor|
Photo credits: François de Ribaucourt, C. Lamy