Pr Serge Goldman, responsable (Erasme)
sgoldman@ulb.ac.be
Serge Goldman was born in 1957 and he studied at the Medical School of the Université Libre de Bruxelles. He is MD with successive certifications in neurology and in nuclear medicine and with a thesis leading to the “agrégation de l’enseignement supérieur” in Medical Science. He is head of the Department of Nuclear Medicine and the PET/Biomedical Cyclotron Unit at ULB - Erasme Hospital since 2002. He got trained in PET imaging during a fellowship at Johns Hopkins University in the research group of Pr. H.N. Wagner. He has published 185 full articles and a dozen of book chapters during the last 25 years. Most of his scientific production relates to PET imaging, including for animal models. His main field of research is imaging of brain tumors with a particular stress put on the integration of molecular imaging in therapy targeting. Other fields of interest are imaging for cell tracking and neurological applications of PET, in particular in the domains of neurodegeneration, epilepsy and development. He has been President of the Belgian Society of Nuclear Medicine from 2007 to 2010.
Gilles DOUMONT
gdoumont@ulb.ac.be
Gilles Doumont got his Master in Chemistry in 1999 at the Université Libre de Bruxelles (ULB). He then started a PhD in Molecular Biology in the IBMM-ULB, and graduated in 2005. Oncology constituted his area of interest. In particular he focused on the study of two new mediators of the biological activity of the tumour suppressor p53. To extend his area of competencies in Oncology he started to work as postdoctoral researcher in NKI-AVL, Amsterdam, The Netherlands, an institute entirely dedicated to cancer research. The aim of his research was to identify new critical molecules involved in metastasis development using a mouse model for invasive lobular carcinoma, one of the most invasive breast cancers affecting women. He had the financial support of the European Molecular Biology Organization (EMBO long term fellowship). Back in Belgium in April 2011 Gilles Doumont is working as a researcher at the CMMI.
Nuclear molecular imaging - ex vivo
Équipements
- Le micro-Imager du CMMI (Biospace Lab, France)
Références bibliographiques
- F. Biver, F. Lotstra, M. Monclus, S. Dethy, P. Damhaut, D. Wikler, A. Luxen, and S. Goldman, In vivo binding of [18F] altanserin to rat brain 5HT2 receptors: a fi lm and electronic autoradiographic study, Nucl Med Biol 24, pp 357-60 (1997)
- S.N. Schiffmann, S. Goldman, P. Heyman, M. De Vuyst, G. De Roy, and J.J. Vanderhaeghen, Ontogeny of cholecystokinin receptors in the human striatum, Neurosci Lett 141, pp 39-42 (1992)
- S. Goldman, D. Pelaprat, O. Van Reeth, B. Roques, and J.J. Vanderhaeghen, Autoradiographic localization of cholecystokinin binding sites in human cerebellar system using a [125I]CCK8 probe, Neurochem Int 10, pp 467-471 (1987)
Descriptif et applications
L’Autoradiographie est une technique d’imagerie moléculaire ex vivo planaire (2D) de haute résolution (quelques dizaines de microns), basée sur la détection de particules β émises par un radiotraceur distribué dans des coupes histologiques. La détection est classiquement réalisée par l’exposition d’un film ou d’une émulsion radiosensible directement apposée sur la coupe.
Avec un système tel que le micro-Imager acquis par le CMMI, où l’émulsion scintillante est couplée à une caméra CCD intensifi ée et refroidie, l’autoradiographie est devenue numérique. Celle-ci permet de réaliser des images en temps réel, sans risque de saturation ou de sousexposition, avec une sensibilité meilleure de plusieurs ordres de grandeur, et de fournir des données directement quantitatives (comptage vrai des particules détectées). De plus, elle offre la possibilité de discriminer et d’imager plusieurs isotopes simultanément sur des coupes tissulaires présentant un marquage multiple.
Voir le poster: POSTER_CMMI_-_nuMix.pdf
Voir aussi: http://www.ulb.ac.be/medecine/pet/index2.html; http://homepages.ulb.ac.be/~sgoldman/Site/Home.html
